![]() ![]() Neonatal encephalopathy (NE) resulting from intrapartum related events is a global health problem accounting for a quarter of neonatal deaths world-wide ( 1). This review discusses the role of optical neuromonitoring in NE and why this modality may provide the next significant piece of the puzzle toward understanding the real time state of the injured newborn brain. Increasing use of commercially available cerebral oximeters in the NICU, and the introduction of advanced optical measurements using broadband NIRS (BNIRS), frequency domain NIRS (FDNIRS), and diffuse correlation spectroscopy (DCS) have widened the scope by allowing the direct monitoring of oxygen metabolism and cerebral blood flow, both key to understanding pathophysiological changes and predicting outcome in NE. Research studies within this population have also increased, alongside the development of both instrumentation and signal processing techniques. The clinical use of near-infrared spectroscopy (NIRS) technology has increased in recent years. ![]() There is therefore a real need for a neuromonitoring tool that provides cot side, early and continuous monitoring of brain health which can reliably stratify injury severity, monitor response to current and emerging treatments, and prognosticate outcome. The neuromonitoring technologies currently used in NE however, have limitations in either their availability during the active treatment window or their reliability to prognosticate and stratify injury confidently in the early period following insult. Current neuromonitoring tools provide information utilized for seizure management, injury stratification, and prognostication, whilst systemic monitoring ensures multi-organ dysfunction is recognized early and supported wherever needed. Assessment of injury severity and effective management in the neonatal intensive care unit (NICU) relies on multiple monitoring modalities from systemic to brain-specific. Neonatal encephalopathy (NE) in term and near-term infants is a significant global health problem the worldwide burden of disease remains high despite the introduction of therapeutic hypothermia. 3Edinburgh Neuroscience & Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom.2Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.1Neonatology, EGA Institute for Women's Health, University College London, London, United Kingdom.Please contact Caliber for additional details.Kelly Harvey-Jones 1 Frederic Lange 2 Ilias Tachtsidis 2 Nicola J. All rate lock extensions are subject to Caliber’s standard rate lock extension fees All rate lock extensions are subject to Caliber’s standard rate lock extension fees. Once you identify a property, your rate will be locked for an additional 45 days. ![]() Your rate is protected for up to 30 days to shop for a home. ***The lock will be honored up to 75 days total. Please contact Caliber for additional details. Not all products are available in all states or for all dollar amounts. All products are subject to credit and property approval. Actual terms, including interest rate, are subject to change without prior notice and may vary based on eligibility criteria. **A pre-approval does not signify that all underwriting requirements have been met. Any portion of the discount amount not used toward closing costs will be waived. Advertised discount can only be applied toward payment of closing costs up to a total amount of $1,000 subject to product underwriting guidelines. The offer is nontransferable and can only be used by the intended recipient. Only available for single family primary residences and existing Caliber customers. *Closing cost offer available to customers who apply for a new purchase loan. ![]()
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